Motif ID: FOX{D1,D2}.p2

Z-value: 1.258


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD2chr1_+_47674275-0.581.9e-02Click!
FOXD1chr5_-_72780107-0.048.8e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_159459814 5.062 APOA2
apolipoprotein A-II
chr1_-_159459999 4.317 NM_001643
APOA2
apolipoprotein A-II
chr12_-_9159707 4.009 A2M
alpha-2-macroglobulin
chr12_-_9159780 3.859 A2M
alpha-2-macroglobulin
chr11_-_114880275 3.401 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr12_-_9159789 3.297 NM_000014
A2M
alpha-2-macroglobulin
chr17_-_61655915 3.202 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr5_-_42847716 3.129 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr12_-_9159742 2.878 A2M
alpha-2-macroglobulin
chr7_+_134483305 2.859 NM_018295
TMEM140
transmembrane protein 140
chr10_-_101831579 2.856 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr17_-_6958695 2.723 ASGR2
asialoglycoprotein receptor 2
chr1_-_20682541 2.530


chr17_-_6958773 2.371 NM_001181
NM_080912
NM_080913
ASGR2


asialoglycoprotein receptor 2


chr10_-_44794146 2.286 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr10_+_63331018 2.235 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_119192985 2.152 NM_000127
EXT1
exostosin 1
chr1_-_92124064 2.117 TGFBR3
transforming growth factor, beta receptor III
chr1_-_20685314 2.065 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr17_+_69939130 1.992 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_+_73037382 1.875 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr7_+_134114957 1.765 CALD1
caldesmon 1
chr7_+_134114701 1.748 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr10_-_52315390 1.743 A1CF
APOBEC1 complementation factor
chr2_-_165259334 1.707 COBLL1
COBL-like 1
chr3_+_189413414 1.694 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_92124201 1.657 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr9_-_93164015 1.643 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr9_-_93163965 1.639 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr19_+_18357966 1.638 NM_004864
GDF15
growth differentiation factor 15
chr13_+_112825113 1.625 NM_000504
F10
coagulation factor X
chr10_-_52315436 1.602 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr3_-_126088530 1.589 ITGB5
integrin, beta 5
chr7_-_87180499 1.567 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr2_-_188086612 1.508 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr3_-_95175588 1.464 NM_000313
PROS1
protein S (alpha)
chr15_+_97009194 1.462 IGF1R
insulin-like growth factor 1 receptor
chr7_+_94377145 1.438 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr3_-_95175282 1.427 PROS1
protein S (alpha)
chr3_-_150569574 1.423 TM4SF1
transmembrane 4 L six family member 1
chr10_-_90740935 1.408 NM_001141945
ACTA2
actin, alpha 2, smooth muscle, aorta
chr8_-_134378630 1.335 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr8_+_40130143 1.320 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr2_+_96845704 1.305 NM_017623
NM_199078
CNNM3

cyclin M3

chr22_+_36928972 1.302 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr4_+_124537334 1.238 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr3_+_23962518 1.235 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chrY_+_2769596 1.227 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr11_+_22652894 1.213 NM_005256
GAS2
growth arrest-specific 2
chr1_-_27113018 1.178 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr15_-_58671929 1.140 NM_134262
RORA
RAR-related orphan receptor A
chr2_-_65447370 1.128 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr3_-_187309442 1.091 NM_004454
ETV5
ets variant 5
chr3_-_150903749 1.088 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr8_+_126511739 1.083 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr22_+_36928011 1.079 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr2_-_188127294 1.078 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr10_+_7785347 1.077 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 1.073 ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_254205 1.072 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr2_-_165133239 1.071 GRB14
growth factor receptor-bound protein 14
chr14_-_73620912 1.068 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr12_+_99391870 1.061 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr2_-_188127430 1.060 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr12_+_99391681 1.039 NM_005123
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr22_+_19458378 1.026 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr10_+_7785235 1.022 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_111975618 1.021 NM_005962
MXI1
MAX interactor 1
chr8_-_17811750 1.007 FGL1
fibrinogen-like 1
chr10_+_111959978 0.975 NM_001008541
MXI1
MAX interactor 1
chr6_+_17708483 0.972 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr2_+_176761552 0.971 NM_024501
HOXD1
homeobox D1
chr1_-_167822248 0.955 F5
coagulation factor V (proaccelerin, labile factor)
chr1_-_60164912 0.936 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr14_-_73620826 0.928 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chrY_+_2769630 0.927 RPS4Y1
ribosomal protein S4, Y-linked 1
chr3_-_101316038 0.921 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr14_+_22136968 0.920 NM_022060
ABHD4
abhydrolase domain containing 4
chr1_+_225194622 0.914 ADCK3
aarF domain containing kinase 3
chr10_+_7785290 0.911 ITIH2
inter-alpha (globulin) inhibitor H2
chr3_-_58497913 0.901 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr1_-_167822334 0.895 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr5_-_16795336 0.895 MYO10
myosin X
chr1_+_227506751 0.884 NM_006542
SPHAR
S-phase response (cyclin related)
chr1_+_225194582 0.883 ADCK3
aarF domain containing kinase 3
chr12_-_69837831 0.880 TSPAN8
tetraspanin 8
chr1_+_225194616 0.873 ADCK3
aarF domain containing kinase 3
chr20_-_49818268 0.871 ATP9A
ATPase, class II, type 9A
chr1_-_85816520 0.866 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_60165049 0.862 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr10_+_123912930 0.860 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_+_23961739 0.854 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr1_-_12599934 0.851 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr10_+_123913094 0.850 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr17_+_2627099 0.848 RAP1GAP2
RAP1 GTPase activating protein 2
chr1_-_24342158 0.847 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr12_-_101835026 0.842 PAH
phenylalanine hydroxylase
chr1_+_225194560 0.842 NM_020247
ADCK3
aarF domain containing kinase 3
chr10_-_54201400 0.838 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr14_-_93859394 0.832 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr16_-_55876075 0.829 NM_015993
PLLP
plasmolipin
chr3_-_115825742 0.821 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr20_-_49818306 0.820 NM_006045
ATP9A
ATPase, class II, type 9A
chr2_+_11591692 0.819 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr9_-_135922912 0.817 NM_007371
BRD3
bromodomain containing 3
chr20_+_43468617 0.815 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr16_-_55876099 0.794 PLLP
plasmolipin
chr9_-_135923373 0.782 BRD3
bromodomain containing 3
chr2_+_101680594 0.778 NM_004834
NM_145686
NM_145687
MAP4K4


mitogen-activated protein kinase kinase kinase kinase 4


chr9_-_134809816 0.768 NM_000368
NM_001162426
NM_001162427
TSC1


tuberous sclerosis 1


chr4_+_140806536 0.763 MGST2
microsomal glutathione S-transferase 2
chr13_-_40138607 0.752 NM_002015
FOXO1
forkhead box O1
chr5_-_111119846 0.752 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr19_-_7244876 0.736 NM_000208
NM_001079817
INSR

insulin receptor

chr8_-_13018123 0.734 NM_001164271
DLC1
deleted in liver cancer 1
chr4_+_140806371 0.728 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr12_-_51629874 0.720 KRT8
keratin 8
chr20_+_44771532 0.719 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr20_+_21054623 0.715 NM_001163022
NM_001163023
NM_018474
PLK1S1


polo-like kinase 1 substrate 1


chr18_+_58533597 0.714 NM_194449
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1
chr11_-_101828563 0.704 NM_052932
TMEM123
transmembrane protein 123
chr14_+_23653819 0.685 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr11_+_101488380 0.682 NM_001195045
YAP1
Yes-associated protein 1
chr2_+_73973600 0.681 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr20_-_33705244 0.673 NM_003915
CPNE1
copine I
chr14_+_23653848 0.673 DCAF11
DDB1 and CUL4 associated factor 11
chr1_-_27689129 0.670 WASF2
WAS protein family, member 2
chr14_+_23653745 0.669 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr17_+_38306339 0.667 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr11_+_46358909 0.658 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr18_+_64616296 0.656 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr2_+_73973640 0.654 ACTG2
actin, gamma 2, smooth muscle, enteric
chr14_+_23654161 0.648 DCAF11
DDB1 and CUL4 associated factor 11
chr6_+_123152044 0.635 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr6_+_64403685 0.632 PHF3
PHD finger protein 3
chr12_-_55990512 0.630 NM_014925
R3HDM2
R3H domain containing 2
chr2_-_215967442 0.628 FN1
fibronectin 1
chr1_+_63861474 0.625 NM_001172818
PGM1
phosphoglucomutase 1
chr7_+_134114912 0.624 CALD1
caldesmon 1
chr17_+_50699965 0.620 HLF
hepatic leukemia factor
chr12_-_69838045 0.617 NM_004616
TSPAN8
tetraspanin 8
chr8_-_28299850 0.609 NM_018660
ZNF395
zinc finger protein 395
chr3_-_79899748 0.609 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr16_-_55875953 0.607 PLLP
plasmolipin
chrX_+_146801142 0.605 NM_001185075
NM_001185076
NM_001185081
NM_001185082
NM_002024
FMR1




fragile X mental retardation 1




chr16_+_2593351 0.604 LOC652276
hypothetical LOC652276
chr4_+_155703581 0.596 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr7_+_65056876 0.596 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr1_+_149897334 0.593 SNX27
sorting nexin family member 27
chr11_+_22644732 0.585 NM_001143830
GAS2
growth arrest-specific 2
chr1_+_144149794 0.580 NM_006472
TXNIP
thioredoxin interacting protein
chr14_+_49304533 0.576 NM_014315
KLHDC2
kelch domain containing 2
chr14_+_49304657 0.572 KLHDC2
kelch domain containing 2
chr17_-_62671767 0.571 NM_014877
HELZ
helicase with zinc finger
chr6_+_64403936 0.569 PHF3
PHD finger protein 3
chr18_-_490583 0.568 NM_130386
COLEC12
collectin sub-family member 12
chr10_-_90702490 0.562 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_+_23654307 0.561 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr22_-_30016707 0.559 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr19_-_52426055 0.559 NM_014417
BBC3
BCL2 binding component 3
chr17_-_62671738 0.556 HELZ
helicase with zinc finger
chr6_+_64414389 0.552 NM_015153
PHF3
PHD finger protein 3
chr16_-_56389176 0.548 NM_001130099
KIFC3
kinesin family member C3
chr17_-_23686566 0.547 NM_174887
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr6_+_64403631 0.545 PHF3
PHD finger protein 3
chr10_+_7785360 0.542 ITIH2
inter-alpha (globulin) inhibitor H2
chr20_+_62357490 0.540 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr1_-_20179495 0.536 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr12_-_74711642 0.531 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_-_32257768 0.528 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chr1_-_172153087 0.518 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_103901171 0.517 MANBA
mannosidase, beta A, lysosomal
chr2_+_109909139 0.506 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr13_-_47885248 0.506 LPAR6
lysophosphatidic acid receptor 6
chr10_+_123738678 0.505 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr19_+_40321584 0.502 FXYD1
FXYD domain containing ion transport regulator 1
chr18_-_44729700 0.499 NM_001190822
SMAD7
SMAD family member 7
chr16_+_20328355 0.496 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr10_-_92671005 0.496 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr19_-_50601406 0.494 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr17_+_54997667 0.490 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr1_-_158759606 0.488 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr12_-_121767272 0.485 NM_006018
GPR109B
G protein-coupled receptor 109B
chr12_-_90100733 0.484 NM_001920
DCN
decorin
chr3_-_188935363 0.483 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr2_+_17585287 0.480 NM_003385
VSNL1
visinin-like 1
chr2_+_200879040 0.476 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr22_-_30018329 0.475 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr1_-_56817823 0.474 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_31650069 0.473 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr2_+_101874765 0.468 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr4_+_100704262 0.467 NM_000253
MTTP
microsomal triglyceride transfer protein
chr19_+_40322231 0.465 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr6_+_64403668 0.464 PHF3
PHD finger protein 3
chr19_+_40321567 0.462 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr3_+_54131731 0.456 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr12_-_31370305 0.456 FAM60A
family with sequence similarity 60, member A
chr13_-_37341859 0.455 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr3_+_54131613 0.453 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr7_-_6065199 0.452 EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.33 2.19e-02 GO:0031093 platelet alpha granule lumen
3.93 2.50e-02 GO:0031091 platelet alpha granule
4.24 2.65e-02 GO:0034774 secretory granule lumen
4.07 3.81e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen

Nothing significant found in function category.